There\u2019s new evidence that not taking care of your gums may\ncontribute to your risk of Alzheimer\u2019s. It\u2019s not much of a stretch when you\nconsider that both involve plaques.<\/p>\n\n\n\n
The link between gum disease and memory\u00a0issues<\/strong><\/p>\n\n\n\n Researchers from Cortexyme, Inc., a pharmaceutical company working on Alzheimer\u2019s treatments, studied the role of a particular bacterium, called P. gingivalis, in mice. The same bacterium is found in people who have been diagnosed with Alzheimer\u2019s. Not surprising, the researchers found that mice with P. gingivalis has an increased production of beta-amyloid, a marker of the neurological disease, in their brain.<\/p>\n\n\n\n Upon studying gingipains, the toxic enzymes of the P.\ngingivalis bacterium, the researchers found a link between high gingipain\nlevels and the presences of tau and ubiquitin, two proteins linked to\nAlzheimer\u2019s.<\/p>\n\n\n\n Potential treatments <\/strong><\/p>\n\n\n\n After creating a series of therapies to block the P.\ngingivalis gingipains, the researchers determined that COR388 was the most\neffective inhibitor. They used the COR388 to decrease the P. gingivalis, which\ndecreased inflammation in the brain. The COR388 also stopped beta-amyloid from\nbeing produced. In addition, the compound protected neurons in the area of the\nbrain that are primarily responsible for memory.<\/p>\n\n\n\n Existing trials have found that COR388 is showing some results in both people with Alzheimer\u2019s and those who don\u2019t have the disease. A larger clinical trial is in the works to test COR388 on people with mild to moderate forms of the disease.<\/p>\n\n\n\n The results of the study were published in the journal Science Advances.<\/em><\/p>\n\n\n\n \u201cDespite significant funding and the best efforts of\nacademic, industry and advocacy communities, clinical progress against\nAlzheimer\u2019s has been frustratingly slow,\u201d says study coauthor Casey Lynch. \u201cThe\nScience Advances publication sheds light on an unexpected driver of Alzheimer\u2019s\npathology\u2014the bacterium commonly associated with chronic periodontal\ndisease\u2014and details the promising therapeutic approach Cortexyme is taking to\naddress it with COR388.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":" There\u2019s new evidence that not taking care of your gums may contribute to your risk of Alzheimer\u2019s. It\u2019s not much of a stretch when you consider that both involve plaques. The link between gum disease and memory\u00a0issues Researchers from Cortexyme, Inc., a pharmaceutical company working on Alzheimer\u2019s treatments, studied the role of a particular bacterium, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[690],"tags":[823,841,838,959,960,889],"class_list":["post-13295","post","type-post","status-publish","format-standard","hentry","category-wellness","tag-aging","tag-alzheimers","tag-dementia","tag-gum-disease","tag-gum-health","tag-memory"],"_links":{"self":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts\/13295","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/comments?post=13295"}],"version-history":[{"count":0,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts\/13295\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/media?parent=13295"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/categories?post=13295"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/tags?post=13295"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}