{"id":14572,"date":"2019-12-11T01:18:58","date_gmt":"2019-12-11T01:18:58","guid":{"rendered":"https:\/\/www.healthymale.com\/squad\/?p=14572"},"modified":"2019-12-11T01:18:58","modified_gmt":"2019-12-11T01:18:58","slug":"diabetes-drug-has-anti-aging-effects","status":"publish","type":"post","link":"https:\/\/www.healthymale.com\/blog\/diabetes\/diabetes-drug-has-anti-aging-effects\/","title":{"rendered":"Diabetes Drug Has Anti-Aging Effects"},"content":{"rendered":"<p><span style=\"font-weight: 400\">There\u2019s new evidence that a commonly prescribed diabetes drug, metformin, may also help promote healthy aging.<\/span><\/p>\n<p><b>\u00a0<\/b><b>A diabetes drug\u2019s anti-aging effects<\/b><\/p>\n<p><span style=\"font-weight: 400\">Previous research found that metformin might help a variety of conditions, including cancer, obesity, nonalcoholic fatty liver disease, polycystic ovary syndrome and metabolic syndrome. The diabetes drug also appears to have the ability to protect bone, especially in early rheumatoid arthritis.<\/span><\/p>\n<p><span style=\"font-weight: 400\">For the new study, a team of researchers from three organizations\u2014the Scripps Research Institute, Weill Cornell Medical College and the Salk Institute for Biological Studies\u2014wanted to better understand how the diabetes drug metformin might worth through signaling pathways independent of the AMPK pathway.<\/span><\/p>\n<p><span style=\"font-weight: 400\">They studied the benefits of metformin through its interaction with two pathways: MAPKAPK2 and protein kinase D. They found hundreds of kinases that rapidly respond to metformin and switch cell processes on and off. In addition, the scientists identified cell mechanisms and new targets controlled by the AMPK pathway, which may also be controlled by metformin.<\/span><\/p>\n<p><span style=\"font-weight: 400\">\u201cThe results broaden our understanding of how metformin induces a mild stress that triggers sensors to restore metabolic balance,\u201d explains Professor Reuben J. Shaw, \u201cexplaining some of the benefits previously reported, such as extended healthy aging in model organisms taking metformin.\u201d<\/span><\/p>\n<p><span style=\"font-weight: 400\">More research needs to be done and the researchers already have plans to study MAPKAPK2 and protein kinase D to determine how metformin might benefit those without diabetes.<\/span><\/p>\n<p><b>What is metformin?<\/b><\/p>\n<p><span style=\"font-weight: 400\">Combined with diet and exercise, metformin is a type 2 diabetes medicine that helps diabetics age 10 and over manage their blood sugar. It\u2019s been used for more than 60 years to help type 2 diabetes reach their A1C goal.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Metformin can cause some side effects, including nausea, diarrhea and upset stomach, but it has been determined to be relatively safe. If you\u2019re on it, talk to your doctor about lactic acidosis, a serious condition that\u2019s caused by a build-up of lactic acid in the blood.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>There\u2019s new evidence that a commonly prescribed diabetes drug, metformin, may also help promote healthy aging. \u00a0A diabetes drug\u2019s anti-aging effects Previous research found that metformin might help a variety of conditions, including cancer, obesity, nonalcoholic fatty liver disease, polycystic ovary syndrome and metabolic syndrome. The diabetes drug also appears to have the ability to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"footnotes":""},"categories":[753],"tags":[714],"class_list":["post-14572","post","type-post","status-publish","format-standard","hentry","category-diabetes","tag-diabetes"],"_links":{"self":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts\/14572","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/comments?post=14572"}],"version-history":[{"count":0,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/posts\/14572\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/media?parent=14572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/categories?post=14572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.healthymale.com\/blog\/wp-json\/wp\/v2\/tags?post=14572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}