Genital herpes (HSV) affects 1 in 6 adults globally. While incurable, modern treatments can reduce outbreaks by up to 80% and transmission risk by ~50%. This guide covers antiviral therapies, prevention strategies, and lifestyle management to support long-term sexual health.
Antiviral Treatment Options
Oral Prescription Medications
Medication |
Best For |
Dosing Protocol |
Valacyclovir |
1st-line suppression & outbreaks |
Outbreak: 500mg 2x/day × 3d Suppression: 500mg daily |
Acyclovir |
Cost-effective management |
Outbreak: 400mg 3x/day × 5d Suppression: 400mg 2x/day |
Doxy PEP |
Bacterial STI prevention (not HSV) |
200mg within 72h of unprotected sex |
Topical Agents
Medication |
Use Case |
Application |
Denavir® |
Cold sores (HSV-1) |
Apply q2h × 4 days |
Zinc Oxide |
Sore healing (OTC) |
Apply to dry ulcers |
Key Differences: Valacyclovir has ~55% better absorption than acyclovir. Brand vs. generic (Valtrex® = Valacyclovir) are clinically identical.
Prevention & Partner Protection
- Daily Antivirals: Reduce shedding days by 70%
- Condoms: Cut female-to-male transmission risk by 65%
- Disclosure: Discuss before intimacy and abstain during outbreaks
- Vaccines in Trial: 2025 mRNA vaccines show 90% efficacy (Phase 2)
Note: Doxy PEP prevents bacterial STIs (chlamydia, gonorrhea, syphilis) but not herpes.
Living Fully with Herpes
“HSV is a manageable skin condition – not a life sentence. With modern antivirals, most people have fewer than 2 outbreaks per year and maintain vibrant sex lives.”
– Dr. Elena Rodriguez, STI Specialist