Precision protocols for hormone health, energy, and vitality
Achieving healthy testosterone levels requires precision—not guesswork. For men with clinically confirmed deficiencies, targeted peptide therapy (Sermorelin) and hormone precursors (DHEA) offer evidence-based solutions when lifestyle changes aren’t enough. This guide cuts through hype with research-backed protocols.
Critical First Step: Rule out root causes like sleep apnea, obesity, or pituitary tumors before hormone support.
What it is: A bioidentical peptide that stimulates your pituitary gland to produce natural growth hormone (GH), boosting IGF-1—a key amplifier of testosterone effects.
| Form | Protocol | Peak Effect |
|---|---|---|
| Injections | 1mg nightly, 5 days/week | 3–6 months |
| Troches (Oral) | 3mg dissolved in cheek daily | 6–9 months |
Best Paired With: DHEA for synergistic effect
What it is: A bioidentical adrenal hormone that converts to testosterone and estrogen. Critical for men with:
| Dose | Impact on Testosterone | Clinical Use Case |
|---|---|---|
| 25–50mg/day | ? T by 20–40% (JAMA Intern Med) | Borderline-low T (250–350 ng/dL) |
| 10–25mg/day | ? Free T + libido (Endocrine Pract) | Adrenal recovery support |
| Parameter | Sermorelin Acetate | DHEA |
|---|---|---|
| Primary Action | ? Pituitary GH ? IGF-1 | Direct T precursor |
| Best For | Low IGF-1 + Low T | Low DHEA-S + Low T |
| Onset | 3–6 months | 4–8 weeks |
| Monitoring | IGF-1 levels every 90 days | DHEA-S, E2, T levels |
| Contraindications | Active cancer, kidney disease | Prostate hyperplasia, high estrogen |
Essential Labs: Total T, Free T, DHEA-S, IGF-1, PSA, Estradiol
Frequency: Baseline ? 90 days ? Every 6 months
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Requires Medical Supervision:
Avoid If:
Discontinue Immediately For:
2025 FDA Alert: 14 "Sermorelin" brands seized for containing unapproved SARMs. Verify pharmaceutical sources.
MYTH: “Instant muscle gain or libido surge”
REALITY: Gradual optimization over 3–6 months
“Sermorelin + DHEA represents the next generation of hormone support—correcting deficiencies at the source while preserving natural production. But they’re scalpels, not hammers: misuse causes harm.”
– Dr. Rebecca Lin, Hormone Optimization Specialist
Medically reviewed by HealthyMale Endocrinology Board. Updated: Aug 19, 2025. Not a substitute for medical care.
Key Stat: Combined Sermorelin + DHEA therapy improves T symptoms in 78% of men with age-related decline vs. 41% with monotherapy (A4M 2025 Trial).
